Why are there clinical trials?
Clinical trials are research studies in which people help doctors find ways to improve health and cancer care. Each study tries to answer scientific questions and to find better ways to prevent, diagnose, or treat cancer.A clinical trial is one of the final stages of a long and careful cancer research process. Studies are done with cancer patients to find out whether promising approaches to cancer prevention, diagnosis, and treatment are safe and effective.
To find out more about clinical trials
http://www.cancer.gov/clinicaltrials or http://swog.org/Visitors/studies.asp
Open Clinical Trials at Blue Water Oncology
NSABP B31 BREAST CANCER
Phase III Randomized Study of Doxorubicin and Cyclophosphamide Followed By Paclitaxel With or Without Trastuzumab (Herceptin) in Women With Node-Positive Breast Cancer That Overexpresses HER2
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy plus trastuzumab is more effective than combination chemotherapy alone for treating breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without trastuzumab in treating women who have node-positive stage II or stage IIIA breast cancer that overexpresses HER2.
http://www.nsabp.pitt.edu/B31_Press_Info.htm
http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=67269&protocolsearchid=1352052&version=patient
http://clinicaltrials.gov/ct/show/NCT00004067?order=1
NSABP B35 BREAST CANCER
Anastrozole Compared With Tamoxifen After Lumpectomy in Treating Postmenopausal Women With Ductal Carcinoma in Situ
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Tamoxifen may fight breast cancer by blocking the uptake of estrogen. Anastrozole may fight breast cancer by decreasing estrogen production. It is not yet known whether anastrozole is more effective than tamoxifen in preventing the recurrence of breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of anastrozole to that of tamoxifen after lumpectomy in preventing the recurrence of breast cancer in postmenopausal women who have ductal carcinoma in situ and are undergoing radiation therapy.
http://www.nsabp.pitt.edu/B35_Information.htm
http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=269539&version=Patient&protocolsearchid=1352061
http://clinicaltrials.gov/ct/show/NCT00053898?order=1
NSABP B36 BREAST CANCER
Comparison of Two Combination Chemotherapy Regimens With or Without Celecoxib in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, epirubicin, cyclophosphamide, and doxorubicin, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Combining chemotherapy with celecoxib may kill more tumor cells. It is not yet known which combination chemotherapy regimen with or without celecoxib is more effective in treating breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens with or without celecoxib in treating women who have undergone surgery for breast cancer that has not spread to the lymph nodes
http://www.nsabp.pitt.edu/B36_Information.htm
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=372952&version=patient
http://clinicaltrials.gov/ct/show/NCT00087178?order=1
NASBP P3 COLON CANCER
Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known whether celecoxib is effective in preventing polyps in patients with colon cancer.
PURPOSE: Randomized phase III trial to study the effectiveness of celecoxib in preventing the development of polyps in patients who have undergone surgery for stage I colon cancer.
http://www.nsabp.pitt.edu/P-3.htm
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=373869&version=patient
http://clinicaltrials.gov/ct/show/NCT00087256?order=8
SWOG E-4697 MELANOMA – SKIN CANCER
Vaccine Therapy and/or Sargramostim in Treating Patients With Locally Advanced or Metastatic Melanoma
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Colony-stimulating factors such as sargramostim increase the number of immune cells found in bone marrow or peripheral blood. It is not yet known which treatment regimen is more effective for metastatic melanoma.
PURPOSE: Randomized phase III trial to determine the effectiveness of peptide vaccine therapy and/or sargramostim in treating patients who have locally advanced or metastatic melanoma.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1864
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=67568&version=patient
http://clinicaltrials.gov/ct/show/NCT00005034?order=1
SWOG E-5597 NON-SMALL CELL LUNG CANCER
Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known if selenium is effective in preventing the growth of new tumors in patients with previously resected non-small cell lung cancer.
PURPOSE: Randomized phase III trial to determine the effectiveness of selenium in preventing the development of second primary lung tumors in patients who have undergone surgery to remove stage I non-small cell lung cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1826
http://clinicaltrials.gov/ct/show/NCT00008385?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68402&version=patient
SWOG N-9831 BREAST CANCER
Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy is more effective with or without trastuzumab in treating breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without trastuzumab in treating women who have breast cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1806
http://clinicaltrials.gov/ct/show/NCT00005970?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=67953&version=patient
SWOG R-9811 ANAL CANCER
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more effective than fluorouracil and cisplatin plus radiation therapy for anal cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of fluorouracil and mitomycin plus radiation therapy with that of fluorouracil and cisplatin plus radiation therapy in treating patients who have stage II or stage III anal cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1831
http://clinicaltrials.gov/ct/show/NCT00003596?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=66667&version=patient
SWOG E1A02 WALDENSTROM’S MACROGLOBULINEMIA
Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Waldenstrom's Macroglobulinemia
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Combining rituximab with combination chemotherapy may kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of combining rituximab with combination chemotherapy in treating patients who have newly diagnosed Waldenstrom's macroglobulinemia.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1949
http://clinicaltrials.gov/ct/show/NCT00060346?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=301634&version=patient
SWOG S-9910 LEUKEMIA ANCILLARY
Leukemia Centralized Reference Laboratories and Tissue Repositories, Ancillary
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=57
SWOG S-9912 OVARIAN, CANCER, FALLOPIAN TUBE CANCER, PERITONEAL CANCER
Combination Chemotherapy in Treating Women With Stage III Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining paclitaxel, cisplatin, and liposomal doxorubicin in treating women who have undergone surgery for stage III ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=59
http://clinicaltrials.gov/ct/show/NCT00003896?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=67066&version=patient
SWOG S0001 GLIOBLASTOMA MULTIFORE, GLIOSARCOMA
Radiation Therapy and Carmustine With or Without O6-Benzylguanine in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. O6-benzylguanine may help carmustine kill more tumor cells by making tumor cells more sensitive to the drug. It is not yet known whether radiation therapy and carmustine are more effective with or without O6-benzylguanine.
PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus carmustine with or without O6-benzylguanine in treating patients who have newly diagnosed glioblastoma multiforme or gliosarcoma.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1852
http://clinicaltrials.gov/ct/show/NCT00017147?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68656&version=patient
SWOG S0008 MELANOMA
Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill melanoma cells. It is not yet known whether interferon alfa is more effective with or without combination chemotherapy and interleukin-2 for melanoma.
PURPOSE: Randomized phase III trial to compare the effectiveness of interferon alfa with or without combination chemotherapy consisting of cisplatin, vinblastine, and dacarbazine, plus interleukin-2, in treating patients who have melanoma.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1797
http://clinicaltrials.gov/ct/show/NCT00006237?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68162&version=patient
SWOG S0028 URINARY TRACT CANCER
Gemcitabine and Paclitaxel in Treating Patients With Advanced or Recurrent Cancer of the Urinary Tract
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining gemcitabine and paclitaxel in treating patients who have advanced or recurrent cancer of the urinary tract.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1844
http://clinicaltrials.gov/ct/show/NCT00022633?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68837&version=patient
SWOG S0114 VACCINES
Vaccine Therapy in Treating Patients With Gastric Cancer, Non-Small Cell Lung Cancer, Prostate, or Ovarian Cancer
RATIONALE: Vaccines made from a peptide may make the body build an immune response to kill cancer cells.
PURPOSE: Phase I trial to compare two different vaccines in treating patients who have gastric cancer, non-small cell lung cancer, prostate, or ovarian cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1888
http://clinicaltrials.gov/ct/show/NCT00023634?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68824&version=patient
SWOG S0124 SMALL CELL LUNG CANCER
Cisplatin Combined With Either Irinotecan or Etoposide in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether cisplatin combined with irinotecan is more effective than cisplatin combined with etoposide in treating extensive-stage small cell lung cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of cisplatin combined with either irinotecan or etoposide in treating patients who have extensive-stage small cell lung cancer.
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=68824&version=patient
http://clinicaltrials.gov/ct/show/NCT00045162?order=1
http://clinicaltrials.gov/ct/show/NCT00045162?order=1
SWOG S0205 PANCREATIC CANCER
Gemcitabine With or Without Cetuximab as First-Line Therapy in Treating Patients With Locally Advanced Unresectable or Metastatic Adenocarcinoma of the Pancreas
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as cetuximab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether gemcitabine is more effective with or without cetuximab in treating pancreatic cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of gemcitabine with or without cetuximab as first-line therapy in treating patients who have locally advanced unresectable or metastatic adenocarcinoma of the pancreas.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1933
http://clinicaltrials.gov/ct/show/NCT00075686?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=347414&version=patient
SWOG S0215 BREAST CANCER
Trastuzumab, Docetaxel, Vinorelbine, and Filgrastim in Treating Women With Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as trastuzumab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Colony-stimulating factors, such as filgrastim, may help a person's immune system recover from the side effects of chemotherapy.
PURPOSE: Phase II trial to study the effectiveness of combining trastuzumab with docetaxel, vinorelbine, and filgrastim in treating women who have stage IV breast cancer.
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=1879
http://clinicaltrials.gov/ct/show/NCT00041067?order=1
http://cancer.gov/search/ViewClinicalTrials.aspx?cdrid=69440&version=patient
SWOG 9007 LEUKEMIA
Cytogenetic Studies in Leukemia Patients
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=4
SWOG 9205 PROSTATE
Central Prostate Cancer Serum Repository Protocol
http://swog.org/Visitors/ViewProtocolDetails.asp?ProtocolID=7
Posted by BWONC. Direct Link this article. | Comments (0)